1. WeAudition look:husband
Hi all, I'm a SAGe actor based in Los Angeles. I have been in a variety of commercial, industrial, and film projects. I'm always interested in helping others ...
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2. [PDF] ANDOVER----- 1 - Memorial Hall Library
8 dec 1994 · Alliance Against Drugs, to speak on drug prevention. Call the YMCA ... The Yoshida family is enriched by Brent. (Conlinued Lorn page 42).
3. The Cocaine and Oxycodone Biobanks, Two Repositories ... - NCBI
16 jun 2021 · Experimental design of addiction-like behavior phenotyping and sampling. Timeline of behavioral tests and biological sampling relative to drug ...
The rat oxycodone and cocaine biobanks contain samples that vary by genotypes (by using genetically diverse genotyped HS rats), phenotypes (by measuring addiction-like behaviors in an advanced SA model), timepoints (samples are collected longitudinally ...
4. Large-scale characterization of cocaine addiction-like behaviors ...
14 sep 2023 · Addiction is commonly characterized by escalation of drug intake, compulsive drug seeking, and continued use despite harmful consequences.
Cocaine use disorder remains a serious public health problem in the USA, with 2.2 million regular cocaine users in 2019 and over a million individuals with cocaine use disorder in the past year (SAMHSA, 2019). The use of cocaine is associated with substantial morbidity and elevated rates of healthcare utilization (Butler et al., 2017), and over the last 10 years, the number of cocaine-related deaths has quadrupled (Hedegaard et al., 2018). A key unanswered question for addiction research remains why casual patterns of drug consumption escalate to problematic patterns associated with high motivation and a compulsive-like pattern of drug use in some individuals, but not others and how sex may affect this trajectory (George and Koob, 2017; Piazza and Deroche-Gamonet, 2013). Although addiction affects both males and females, most preclinical studies have focused on males (Beery and Zucker, 2011; Shansky and Murphy, 2021). Even in studies that use males and females, low sample size often makes it difficult to draw reliable conclusions about the role of sex differences in addiction vulnerability (Becker and Koob, 2016; Carroll and Lynch, 2016). To investigate the critical questions about how sex and individual differences interact to produce the vulnerability to develop addiction-like large sample sizes are urgently needed.
5. Nisei | Courage & Conviction - Virtual | Indy Shorts Film Festival - Eventive
Discover the extraordinary power of courage and unwavering conviction as these rousing shorts showcase captivating stories of individuals who defy adversity ...
"Nisei" follows the journey of brothers Minoru and John Miyasaki as they are stripped of their citizenship, sent to internment camps, but still volunteer to join the 442nd Regimental Combat Team, an all Japanese-American regiment during WWII.
6. [PDF] Guard _supports largest drug bust in Maui history - Hawaii DoD
Hercules air- craft transports government offi- cials, detainees and equipment from. Kahului Airport to. Oahu in support of the drug bust. ... Brent K. Rubio ...
7. [PDF] Large-scale characterization of cocaine addiction-like behaviors ...
17 aug 2024 · Addiction is commonly characterized by escalation of drug intake, compulsive drug seeking, and continued use despite harmful consequences.
8. National Underwriter Competitors | Companies like National ...
Its flagship titles, Taber's Cyclopedic Medical Dictionary and Davis's Drug ... National Underwriter Employee Brent Yoshida's profile photo · Brent Yoshida.
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9. Paroxetine—The Antidepressant from Hell? Probably Not, But Caution ...
By the late 1990s, paroxetine frequently was being associated with serious drug interactions and medication side effects. ... Brent DA. Clinical Response ...
Paroxetine, also known by the trade names Aropax, Paxil, Pexeva, Seroxat, Sereupin and Brisdelle, was first marketed in the U.S. in 1992. Effective for major depression and various anxiety disorders, it quickly gained a sizable share of the antidepressant ...
10. Antibody Drug Conjugates for Cancer Therapy: From Metallodrugs ... - MDPI
Kurihara, H.; Hamada, A.; Yoshida, M.; Shimma, S.; Hashimoto, J.; Yonemori ... Drug Conjugate Drug-Linker. In ACS Symposium Series; Pesti, J.A., Abdel ...
This review highlights significant advancements in antibody–drug conjugates (ADCs) equipped with metal-based and nature-inspired payloads, focusing on synthetic strategies for antibody conjugation. Traditional methods such us maleimide and succinimide conjugation and classical condensation reactions are prevalent for metallodrugs and natural compounds. However, emerging non-conventional strategies such as photoconjugation are gaining traction due to their milder conditions and, in an aspect which minimizes side reactions, selective formation of ADC. The review also summarizes the therapeutic and diagnostic properties of these ADCs, highlighting their enhanced selectivity and reduced side effects in cancer treatment compared to non-conjugated payloads. ADCs combine the specificity of monoclonal antibodies with the cytotoxicity of chemotherapy drugs, offering a targeted approach to the elimination of cancer cells while sparing healthy tissues. This targeted mechanism has demonstrated impressive clinical efficacy in various malignancies. Key future advancements include improved linker technology for enhanced stability and controlled release of cytotoxic agents, incorporation of novel, more potent, cytotoxic agents, and the identification of new cancer-specific antigens through genomic and proteomic technologies. ADCs are also expected to play a crucial role in combination therapies with immune checkpoint inhibitors, CAR-T cells, and small molecule inhibitors, leading to more dur...
11. Brent Ito - Articles - Scientific Research Publishing
... drug-eluting stents (Articles). Shigenori Ito, Kosuke Nakasuka, Satoru Sekimoto, Kazuyuki Miyata, Masahiko Inomata, Takayuki Yoshida, Nozomu Tamai, Tomoaki ...
Brent Ito
